Bovine Ephemeral Fever Virus Uses a Clathrin-Mediated and Dynamin 2-Dependent Endocytosis Pathway That Requires Rab5 and Rab7 as Well as Microtubules

Ebola virus uses clathrin-mediated endocytosis as an entry pathway.

Ebola virus (EBOV) infects several cell types and while viral entry is known to be pH-dependent, the exact entry pathway(s) remains unknown. To gain insights into EBOV entry, the role of several inhibitors of clathrin-mediated endocytosis in blocking infection mediated by HIV pseudotyped with the EBOV envelope glycoprotein (EbGP) was examined. Wild type HIV and envelope-minus HIV pseudotyped wi...

Simian hemorrhagic fever virus cell entry is dependent on CD163 and uses a clathrin-mediated endocytosis-like pathway.

UNLABELLED Simian hemorrhagic fever virus (SHFV) causes a severe and almost uniformly fatal viral hemorrhagic fever in Asian macaques but is thought to be nonpathogenic for humans. To date, the SHFV life cycle is almost completely uncharacterized on the molecular level. Here, we describe the first steps of the SHFV life cycle. Our experiments indicate that SHFV enters target cells by low-pH-dep...

Dynamin- and clathrin-dependent endocytosis in African swine fever virus entry.

African swine fever virus (ASFV) is a large DNA virus that enters host cells after receptor-mediated endocytosis and depends on acidic cellular compartments for productive infection. The exact cellular mechanism, however, is largely unknown. In order to dissect ASFV entry, we have analyzed the major endocytic routes using specific inhibitors and dominant negative mutants and analyzed the conseq...

Dynamin and clathrin - dependent endocytosis in African 1 swine fever virus entry

Departamento de Biotecnologia Instituto Nacional de Investigacion y Tecnologia 6 Agraria y Alimentaria, INIA, Autovia A6 km 7, 28040 Madrid, Spain. 7 [email protected]; [email protected] 8 9 Abbreviations: ASFV, African swine fever virus; CTX, cholera toxin; EM, electron 10 microscopy; Dyn, dynamin; TF, transferrin. 11 Running title: Dynamin and clathrin-mediated endocytosis of ASFV. 12

Isolation of Bovine Ephemeral Fever Virus in Iran